What will it take to cure your most dreaded disease? How about the ability to wrangle with family.
Three women at high risk for Alzheimer's disease offer their brains and bodies to a medical study. After the deaths of their mothers, these daughters are determined to contribute to the search for a cure. This is the latest fight against Alzheimer's - by those with a very personal stake in the battle.
Filmed in an observational style with supplementary interviews, the film follows women from contrasting communities in Wisconsin over five years. Barb and her large family take turns caring for their dying mother in a rural corner of the state. In Milwaukee, Karen struggles to raise her adolescent son after her own mother's passing. Meanwhile, Sigrid, a retiree in a college town, focuses full-time on adopting a lifestyle that she believes can stave off the disease. Each woman visits the research site regularly and undergoes rigorous physical and cognitive tests with researchers on the front lines.
Sigrid participates in the Exercise Study led by Dr. Ozioma Okonkwo. Okonkwo proposes: Is there a relationship between physical activity and Alzheimer's biomarkers? He conducts a series of experiments. Results unfold on camera. Using the human subjects, the scientists learn some of the most important findings in the field today.
With nuance and tenderness, the film interweaves the scientists' quest to find a cure with the personal ups and downs of these women's lives. The intimate access to all of their stories reminds viewers that Alzheimer's is a disease battled on many fronts: in a laboratory, in a home, in a marriage, in a mind, and in one's hopes and fears about the future.